대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
- /
- Pages.312.3-313
- /
- 2002
POTENT INHIBITION OF HUMAN CYTOCHROME P450 1 ENZYMES BY DIMETHOXYPHENYL VINYL THIOPHENE
- Lee, Sang-Kwang (College of Pharmacy, Chungang University, Seoul) ;
- Kim, Sang-Hee (Korea and Natural Products Research Institute, Seoul National Universit, Seoul) ;
- Kim, Mie-Young (Korea and Natural Products Research Institute, Seoul National Universit, Seoul) ;
- Chun, Young-Jin (Korea and Natural Products Research Institute, Seoul National Universit, Seoul)
- 발행 : 2002.10.01
초록
Recently we have reported that various hydroxystilbenes show strong inhibition of human P450 1 activity. A series of synthetic trans-stilbene derivatives were prepared and their inhibitory potentials were evaluated with the bacterial membrane of recombinant human P450 1A1, 1A2 or 1B1 coexpressed with human NADPH-P450 reductase to find new candidates for cancer chemoprevention, Of the compounds tested. SY-021 (3.5-dimethoxyphenyl vinyl thiophene) exhibited a potent inhibition of human P450 181 with an IC
키워드