Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Neuroprotective effects of baicalein. baicalin. and wogonin in primary cultured rat cortical cells

  • Cho, Jung-Sook (College of Medicine, Dongguk University, Kyongju) ;
  • DokGo, Hyang (Korea Research Institute of Bioscience and Biotechnology,Taejon) ;
  • Lee, Kwang-Heun (Korea Research Insitute of Bioscience and Biotechnology,Taejon) ;
  • Lee, Hyung-Kyu (Korea Research Insitute of Bioscience and Biotechnology,Taejon)
  • Published : 2002.10.01
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Abstract

Oxidative stress has been implicated in the pathophysiology of many neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Baicalein. baicalin and wogonin. the major constituents of Scutellaria baicalensis. have been reported to exhibit antioxidant properties in many different bioassay systems. The present study evaluated neuroprotective effects of these flavonoids on various neuronal injuries induced in primary cultured rat cortical cells by oxidative stress. NMDA. oxygen-glucose deprivation. and $A{\beta}$(25-35). (omitted)

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