Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.301.1-301.1
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- 2002
Alteration of Hepatic Drug Metabolizing Function after Traumatic Injury
- Lee, Woo-Yong (College of Pharmacy. Sungkyunkwan University) ;
- Lee, Sang-Ho (College of Pharmacy. Sungkyunkwan University) ;
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Lee, Sun-Mee
(College of Pharmacy. Sungkyunkwan University)
- Published : 2002.10.01
Abstract
The aim of present study was to investigate effects of blunt trauma on alterations in cytochrome P-450 (CYP)-dependent drug metabolizing function and to determine the role of Kupffer cells in the hepatocellular dysfunction Rats underwent closed femur fracture (FFx) with associated soft-tissue injury under anesthesia. Control animals received only anesthesia. To deplete Kupffer cells in vivo, gadolinium chloride (GdCl3) was injected intravenously via the tail vein at 7.5 mg/kg body wt. 1 and 2 days before surgery. (omitted)
Keywords