대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.294.2-295
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- 2002
Role of phospholipid metabolism in Methylmercury-induced Cytotoxicity
- Kang, Mi-Sun (Dept. of Environmental and Health chemistry. College of Pharmacy, Chung-Ang University) ;
- Jeong, Ju-Yeon (Dept. of Environmental and Health chemistry. College of Pharmacy, Chung-Ang University) ;
- Jung, Sung-Yun (Dept. of Environmental and Health chemistry. College of Pharmacy, Chung-Ang University) ;
- Kim, Dae-Kyong (Dept. of Environmental and Health chemistry. College of Pharmacy, Chung-Ang University)
- 발행 : 2002.10.01
초록
Methylmercury (MeHg: CH3HgCl) is a ubiquitous environmental toxicant that readily bioaccumulates in aquatic foodchains. This toxicant is most highly exposed to humans through the ingestion of contaminated food. and thus is an ongoing health concern. Thus far. MeHg has been suggested to exert its toxicity through its high reactivity to thiols of bioactive proteins. elevation in intracellular Ca2＋ concentration. and generation of reactive oxygen species. but its mechanism remains poorly understood. (omitted)
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