대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.293.3-294
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- 2002
Aluminium increase Iron uptake into Glial cells
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Cheong, Jae-Hoon
(Department of Pharmacy, Sahmyook University) ;
- Lim, Sung-Sup (Department of Pharmacy, College of Medicine, Chungnam National University) ;
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Lee, Choong-Jae
(Department of Pharmacy, College of Medicine, Chungnam National University)
- 발행 : 2002.10.01
초록
In the brain, glial cells serve in the role to sequester metal from the neural microenvironment and therefore play an important role as a cellular deposition site. The central nervous system is highly vulnerable to oxidative stress, and free iron can stimulate oxidative stress by the Fenton reaction. Aluminum may upregulates the transferrin-independent iron uptake system and stimulate oxidative stress. Nramp2. also known as DMT 1. is a 12-transmembrane(TM) domain protein responsible for dietary iron uptake as well as metal ions such as iron. lead, mangamese. zinc. copper, and cobait. (omitted)
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