Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.292.2-293
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- 2002
Effects of pyrethroid compounds on alkaline phosphatase activity in estrogen receptor positive human breast cancer cells
- Kim, In-Young (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FAD) ;
- Kang, Il-Hyun (Department of Pharmacy, Duksung Woman′s University) ;
- Shin, Jae-Ho (Department of Pharmacy, Duksung Woman′s University) ;
- Kim, Hyung-Sik (Department of Pharmacy, Duksung Woman′s University) ;
- Lee, Su-Jung (Department of Pharmacy, Duksung Woman′s University) ;
- Moon, Hyun-Ju (Department of Pharmacy, Duksung Woman′s University) ;
- Kim, Tae-Sung (Department of Pharmacy, Duksung Woman′s University) ;
- Shim, Eun-Youn (Department of Pharmacy, Duksung Woman′s University) ;
- Moon, A-Ree (Department of Pharmacy, Duksung Woman′s University) ;
- Choi, Kwang-Sik (Department of Pharmacy, Duksung Woman′s University) ;
- Han, Soon-Young (Department of Pharmacy, Duksung Woman′s University)
- Published : 2002.10.01
Abstract
Pyrethroids are one of the most commonly used insecticides in worldwide. but it remains unclear whether pyrethroid compounds possess endocrine disrupting activity or not. T47D cells, an estrogen receptor positive human breast cancer cell line. is known to induce alkaline phosphatase (AlkP) only in response to progestins. Because the action of estrogen may be changed by the action of progestins (Kraus et al. 1995), it is important to examine the potential to produce progestin-mediated effects for determining endocrine disrupting activity of chemicals(LiLorenzo et al. 1991). (omitted)
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