Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.292.1-292.1
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- 2002
COX-inhibitors down-regulate TCDD-induced cyp1a1 activity in C57BL/6 mouse and Hepa- 1 cells.
- Bang-Sylie (College of Pharmacy, Ewha womans university) ;
- Cho, Min-Jung (College of Pharmacy, Ewha womans universit) ;
- Sheen, Yhun-Yhong (College of Pharmacy, Ewha womans university)
- Published : 2002.10.01
Abstract
In order to understand the mechanism of action of TCDD. we have examined the effect of COX-inhibitors on cypla1 activity. We observed the effect of COX-inhibitor on EROD activity in C57BL/6 mouse in vovo. And we also evaluated the effect of COX-inhibitors on cypla1 mRNA. mouse cyplal promoter activity and EROD activity in Hepa cell. When Aspirin were pretreated with 3MC in vivo, the EROD activity that was stimulated by 3MC was inhibited. (omitted)
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