Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.288.3-289
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- 2002
Protective effect of Platycodon grandiflorum against t-butyl hydroperoxide-induced hepatic toxicity in rats
- Lee, Kyung-Jin (Department of Biology, Chonnam National University) ;
- Choi, Chul-Yung (Department of Pharmacy and Research Center, gor Proteineous Materials, Chosun University) ;
- Jeong, Hye-Gwang (Department of Pharmacy and Research Center, gor Proteineous Materials, Chosun University)
- Published : 2002.10.01
Abstract
Increasing evidence regarding free radical generating agents and inflammatory processes suggests that accumulation of reactive oxygen species can cause hepatotoxicity. A short-chain analog of lipid hydroperoxide, t-butyl hydroperoxide (t-BHP), can be metabolized to free radical intermediates by cytochrome P-450 in hepatocytes. which in turn can initiate lipid peroxidation, affect cell integrity and result in cell injury. (omitted)
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