대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.287.3-288
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- 2002
The toxicity of Aceporol 460 as a novel high loading capacity solubilizer of paclitaxel
- Kim, Yeo-Woon (College of Pharmacy, Ewha Womans University) ;
- Kim, Ja-Young (College of Medicine, Seoul National University) ;
- Cho, Min-Jung (College of Medicine, Seoul National University) ;
- Song, Hae-Won (College of Medicine, Seoul National University) ;
- Lee, Min-Jae (College of Medicine, Seoul National University) ;
- Kim, Jong-Jae (College of Medicine, Seoul National University) ;
- Lee, Mi-Suk (College of Medicine, Seoul National University) ;
- Sheen, Yhun-Yhong (College of Medicine, Seoul National University)
- 발행 : 2002.10.01
초록
Previously. we reported a novel polymeric micellar solubilizeI'. Aceporol 330. that showed relatively low toxic effects when it was compared with that of Cremophor EL which is currently being used for paclitaxel. In this study. we have developed a new micellar solubilizeI, Aceporol 460. that has 3-4 times higher loding capacity for paclitaxel than Aceporol 330. The single-dose and the repeated-dose toxicity of Aceporol 460 were evaluated in ICR mice. (omitted)
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