대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.278.2-279
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- 2002
Tetrandrine induces mitochondria-dependent apoptosis in HepG2 cells
- Hee, Oh-Seon (College of Pharmacy and Medicinal Resources Research Center. Wonkwang University) ;
- Lee, Bang-Wool (College of Pharmacy and Medicinal Resources Research Center. Wonkwang University) ;
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Lee, Byung-Hoon
(College of Pharmacy and Medicinal Resources Research Center. Wonkwang University)
- 발행 : 2002.10.01
초록
Tetrandrine is a bis-benzyl isoquinoline alkaloid derived from the root of Stephania tetrandra S. Moore. which was reported to elicit in vitro cytotoxic effect on HeLa cells and in vivo supprresive effects on mouse ascite tumor. Tetrandrine also induced apoptosis in a various cell lines. Recent studies have revealed that mitochondria has been shown to play an important role in the regulation of apoptotic processes. (omitted)
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