Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Molecular interaction of $G{\alpha}16$ subunit G protein with chemoattractant receptors

  • Ha, Ji-Hee (Department of Pharmacology and Institute of Biomedical Sciences, College of Medicine, Hanyang University) ;
  • Lee, Chang-Ho (Department of Pharmacology and Institute of Biomedical Sciences, College of Medicine, Hanyang University)
  • Published : 2002.10.01
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Abstract

It has been proposed that G protein interacts with receptor via multiple interaction sites. With regard to this, C-terminus of the G${\alpha}$ subunit is clearly not the only structural determinant on the G proteins that is critical for receptor coupling selectivity, but the extreme N-terminus of Ga subunit and other structural elements were proposed to be responsible for dictating the interaction with receptors. (omitted)

Keywords