Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Direct and functional interaction between dopamine D2 receptor and ALY

  • Yang, Ji-Hye (Pharmacology lab. College of Pharmacy, Department of PsychologyIKMS), Chonnam National University) ;
  • Cheong, Da-Woon (Pharmacology lab. College of Pharmacy, Department of PsychologyIKMS), Chonnam National University) ;
  • Seo, Hyung-Ju (Pharmacology lab. College of Pharmacy, Department of PsychologyIKMS), Chonnam National University) ;
  • Kim, Moon-Soo (Pharmacology lab. College of Pharmacy, Department of PsychologyIKMS), Chonnam National University) ;
  • Kim, Kyeong-Man (Pharmacology lab. College of Pharmacy, Department of PsychologyIKMS), Chonnam National University)
  • Published : 2002.10.01
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Abstract

The signaling pathway of D2 dopamine receptor was studied using yeaslt two-hybrid system.. The 3rd cytoplasmic loop of rat D2 dopamine receptor was used to screen the cDNA library of mouse brain. and ALY was found to interact with it. The interaction in the yeast was observed only with the 3rd cytoplasmic loop of D2 dopamine receptor but not with that of D3 or D4 dopamine receptor. The interaction between two proteins was also confirmed by GST pull-down assay. (omitted)

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