Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Pre-conditioning attenuated the $MPP^+$-induced cytotoxicity

  • Lee, Seung-Jin (Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Yang, Sang-In (Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Jang, Choon-Gon (Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Lee, Seok-Yong (Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University)
  • Published : 2002.10.01
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Abstract

MPP$\^$＋/ is known to be a neurotoxic substance that induces the degeneration of dopaminergic neurons and Parkinson-like syndrome. Incubation with MPP$\^$＋/ induced the expression of heme oxygenase-l (HO-1) in PC-12 cells and HO-1 revealed a protective effect against MPP$\^$＋/ -induced cytotoxicity. In this study. we tested the effect of pre-conditioning on the MPP$\^$＋/-induced cytotoxicity. The PC-12 cells were incubated with MPP$\^$＋/ for 3 hrs. and then after 12 hrs the cells were exposed to several concentration of MPP$\^$＋/. (omitted)

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