Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Piperine, a Primary Component of Black Pepper, inhibits Prostagladins Generation by Suppression of COX Activity on Arachidonic Acid Metabolism in LPS-Stimulated RAW264.7 Cells

  • Son, Dong-Ju (College of Natural Sciences, Soonchunhyang University) ;
  • Park, Byeoung-Soo (College of Natural Sciences, Soonchunhyang University) ;
  • Lee, Sung-Eun (College of Agriculture and Life Sciences, Seoul National University) ;
  • Kitatani, Kazuyuki (Department of Pathological Biochemistry, Kyoto Pharmaceutical University) ;
  • Park, Young-Hyun (College of Natural Sciences, Soonchunhyang University)
  • Published : 2002.10.01
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Abstract

Piperine (piperinoyl-piperidine) is a nitrogenous pungent substance contained in black pepper. the well know spice obtained from Piper nigrum L. (Piperaceae). Pharmacological studies have shown that piperine reduces inflammation and pain. possesses anticonvulsant and antiulcer activity. protects the liver and has deleterious effects on testis function. Prostaglandins(PGs) are a family of intercellular and intracellular messengers derived from arachidonic acid(AA) by phospholipase(PL) and cyclooxygenase(COX). (omitted)

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