대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Anti-proliferative Effects of lxeris sonchifolia H. Extracts on Human Hepatocellar Carcinoma Cells

  • Yee, Su-Bog (Dept. of Pharmacy, Dept. of Manufacturing Pharmacy, Pusan National University) ;
  • Park, Hye-Joung (Dept. of Food and Nutrition, Silla University) ;
  • Park, Hwa-Sun (Dept. of Food and Nutrition, Silla University) ;
  • Chung, Sang-Woon (Dept. of Food and Nutrition, Silla University) ;
  • Park, Sang-Eun (Dept. of Food and Nutrition, Silla University) ;
  • Im, Kwang-Sik (Dept. of Pharmacy, Dept. of Manufacturing Pharmacy, Pusan National University) ;
  • Bae, Song-Ja (Dept. of Food and Nutrition, Silla University) ;
  • Hae, Young-Chung (Dept. of Pharmacy, Dept. of Manufacturing Pharmacy, Pusan National University) ;
  • Kim, Nam-Deuk (Dept. of Pharmacy, Dept. of Manufacturing Pharmacy, Pusan National University)
  • 발행 : 2002.10.01
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초록

We investigated the anti-proliferative effects of lxeris sonchifolia H. (godulbaegi) root extracts. luteolin(3'. 4', 5. 7-Q-glucoside and 3'. 4', 5, 7-tetrahydoxyflavone) and apigenin (3', 4'. 5. 7-O-gluconic acid) on HepG2 (p53 wild type) cells. Hep3B (p53 null) cells, and Chang liver cells. In MTT assay 3', 4'.5. 7-tetrahydoxyflavone showed the most efficient anti-proliferative effects on these three cell lines. However, there was no significant anti-proliferative effect on Chang liver cell line in MTT results. (omitted)

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