Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Effects of Aporphine Compounds on Dopamine Biosynthesis in PC12 Cells

  • Jin, Chun-Mei (College of Pharmacy, Chungbuk National University) ;
  • Lee, Jae-Joon (College of Pharmacy, Chungbuk National University) ;
  • Yin, Shou-Yu (College of Pharmacy, Chungbuk National University) ;
  • Kim, Yu-Mi (College of Pharmacy, Chungbuk National University) ;
  • Lee, Myung-Koo (College of Pharmacy, Chungbuk National University) ;
  • Ryu, Si-Yong (Korea Research Institute of Chemical Technology)
  • Published : 2002.10.01
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Abstract

The effects of aporplline isoquinoline alkaloids such as liriodenine. anonaine and asimilobine on dopamine biosynthesis in PC12 cells were investigated. Treatment of PC12 cells with liriodenine (10 ${\mu}$M), anonaine (0.05 ${\mu}$M) and asimilobine (0.15 ${\mu}$M) showed 33.6%, 37.7% and 35.1 % inhibition of dopamine content for 12 h. The IC$\sub$50/ values of liriodenine. anonaine and asimilobine were 8.4 ${\mu}$M. 0.05 ${\mu}$M and 0.13 ${\mu}$M. respectively. (omitted)

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