Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
- /
- Pages.250.2-251
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- 2002
Induction of penile erection in spinal cord-injured rabbits by administration of DA- 8159, a new selective PDE 5 inhibitor
- Ahn, Gook-Jun (Dong-A Phamaceutical Research Institute) ;
- Kang, Kyung-Koo (Dong-A Phamaceutical Research Institute) ;
- Back, Dae-Hyun (Dong-A Phamaceutical Research Institute) ;
- Sohn, Yong-Sung (Dong-A Phamaceutical Research Institute) ;
- Choi, Seul-Min (Dong-A Phamaceutical Research Institute) ;
-
Ahn, Byung-Ok
(Dong-A Phamaceutical Research Institute)
;
- Kwon, Jong-Won (Dong-A Phamaceutical Research Institute) ;
- Kim, Won-Bae (Dong-A Phamaceutical Research Institute)
- Published : 2002.10.01
Abstract
DA-8159 is a new. highly selective. potent cyclic-GMP phosphodiesterase 5 inhibitor developed by Dong-A Pharmaceutical Company(Kyunggi, Korea) as an oral drug for the treatment of erectile dysfunction. NO- cGMP signal transduction pathway plays a key role for relaxation of corpus cavernosal smooth muscle. In this study. the efficacy of DA-8159 was evaluated by measuring the length of uncovered penile mucosa in spinal cord injury(SCI) rabbits. (omitted)
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