대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.247.2-247.2
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- 2002
Induction of apoptosis by benz[f] indole-4.9-dione analog in human lung cancer cells through p53-dependent mechanism
- Lee, Eun-Jin (College of Pharmacy, Ewha Womans University) ;
- Kim, Young-Leem (College of Pharmacy, Ewha Womans University) ;
- Lee, Hyun-Jung (College of Pharmacy, Ewha Womans University) ;
- Suh, Myung-Eun (College of Pharmacy, Ewha Womans University) ;
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Lee, Sang-Kook
(College of Pharmacy, Ewha Womans University)
- 발행 : 2002.10.01
초록
A synthetic naphthoquinone alkaloid. 2-amino-3-ethoxycarbonyl-l-methyl pyrolo (3,2-b) naphtho-4,9-dione (compound 1), showed a potent cytotoxicity in a panel of cancer cell lines with an IC50 ranged from 0.1 to 0.3 microgram/mL. Prompted by a potent cytotoxic activity, the mechanism action study was performed with cultured A549 of human lung cancer cells. Flow cytometric G2-M cell cycle arrest and microscopic investigation was also characterized with apoptotic morphological features. (omitted)
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