대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
- /
- Pages.246.2-247
- /
- 2002
Effects of cationic polyamines under 10 kD range of molecular weight on basic and induced mucin release from airway goblet cells
-
Lee, Choong-Jae
(Department of Pharmacology. College of Medicine. Chungnam National University)
;
- Lee, Jae-Heun (Department of Pharmacology. College of Medicine. Chungnam National University) ;
- Seog, Jeong-Ho (Department of Pharmacology. College of Medicine. Chungnam National University) ;
- Hur, Gang-Min (Department of Pharmacology. College of Medicine. Chungnam National University)
- 발행 : 2002.10.01
초록
In this study. we tried to investigate whether polymerized basic amino acid e.g. poly-L-lysine(PLL) which has the molecular weight under 10 kD significantly affects the physiological and stimulated mucin release from cultured hamster tracheal surface epithelial cells. Confluent primary hamster tracheal surface epithelial(HTSE) cells were metabolically radiolabeled with 3H-glucosamine for 24 hr and chased for 30 min in the presence of either PLLs or adenosine triphosphate(ATP) and PLL to assess the effects on basic or ATP-stimulated 3H-mucin release. (omitted)
키워드