Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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The Antiproliferative Effects of Bile Acids and Their Derivatives on HepG2 Human Hepatocellular Carcinoma Cells

  • Park, Hwa-Sun (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Yee, Su-Bog (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Choi, Hye-Joung (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Chung, Sang-Woon (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Park, Sang-Eun (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Yoo, Young-Hyun (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Kim, Nam-Deuk (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University)
  • Published : 2002.10.01
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Abstract

We studied on the antiproliferative effects of bile acids and their derivatives on HepG2 human hepatocellular carcinoma cells. Ursodeoxycholic acid (UDCA) and its synthetic derivative HS-1030. and chenodeoxycholic acid (CDCA) and its synthetic derivatives. HS-1199 and HS\ulcorner200, were used. We focused on the regulation of cell cycle and induction of apoptosis by these bile acid derivatives. (omitted)

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