Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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4-Hydroxy nonenal (HNE) Induces Apoptosis and Cell Cycle Arrest in Bovine Aortic Endothelial Cells

  • Chung, Sang-Woon (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Yee, Su-Bog (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Choi, Hye-Joung (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Park, Hwa-Sun (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Park, Sang-Eun (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Chung, Hae-Young (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Kim, Nam-Deuk (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University)
  • Published : 2002.10.01
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Abstract

4-Hydroxy nonenal (HNE) is a lipid peroxidation product derived from oxidized $\omega$-6 polyunsaturated fatty acids, such as arachidonic acid. HNE is widely used as a marker of lipid peroxidation. To study the hypothesis that HNE may induce apoptosis and cell cycle arrest, we estimated cytotoxicity of HNE in BAE (bovine aortic endothelial) cells. Anti-proliferative effects were examined by morphological changes and MTT assay after exposure to different time (0-3 hr) and concentration (3-7 ${\mu}$M of HNE. (omitted)

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