대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.243.2-244
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- 2002
High-Throughput Screening for Novel Inhibitors of Protein-Tyrosine Phosphatase-1B
- Lee, In-Ki (Research Laboratories, Dong-A Pharm.Co. Ltd.) ;
- Son, Mi-Won (Research Laboratories, Dong-A Pharm.Co. Ltd.) ;
- Jung, Mi-Young (Research Laboratories, Dong-A Pharm.Co. Ltd.) ;
- Shin, Chang-Yell (Research Laboratories, Dong-A Pharm.Co. Ltd.) ;
- Kim, Dong-Sung (Research Laboratories, Dong-A Pharm.Co. Ltd.) ;
- Kim, Soon-Hoe (Research Laboratories, Dong-A Pharm.Co. Ltd.) ;
- Yoo, Moo-Hi (Research Laboratories, Dong-A Pharm.Co. Ltd.) ;
- Kim, Won-Bae (Research Laboratories, Dong-A Pharm.Co. Ltd.)
- 발행 : 2002.10.01
초록
Protein-tyrosine phosphatases (PTPs) constitute a family of receptor-like and cytoplasmic enzymes. which catalyze the dephosphorylation of phosphotyrosine residues in a variety of receptors and signaling molecules. Thirty subtypes of PTPs have been identified in human genomes. Among PTPs, PTP1 B has been suggested as a negative regulator of insulin signaling. Overexpression of this enzyme has been known as a cause of obesity and type II diabetes, so it is a target for drug discovery. (omitted)
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