Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Hydrogen Peroxide Activates ERK in Cultured Feline Ileal Smooth Muscle Cells

  • Song, Hyun-Ju (Department of Pharmacology, College of Pharmacy, Chung Ang University) ;
  • Lee, Tai-Sang (Department of Pharmacology, College of Pharmacy, Chung Ang University) ;
  • Jeong, Ji-Hoon (Department of Pharmacology, College of Pharmacy, Chung Ang University) ;
  • Park, Joon-Hong (Department of Pharmacology, College of Pharmacy, Chung Ang University) ;
  • Choi, Tae-Sik (Department of Pharmacology, College of Pharmacy, Chung Ang University) ;
  • Lee, Doo-Won (Department of Pharmacology, College of Pharmacy, Chung Ang University) ;
  • Sohn, Uy-Dong (Department of Pharmacology, College of Pharmacy, Chung Ang University)
  • Published : 2002.10.01
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Abstract

H$_2$O$_2$ has been shown to act as a signaling molecule involved in many cellular functions such as oxidant-induced stress, apoptosis, proliferation. In this study, we investigated the action mechanisms of H$_2$O$_2$ on activation of Extracellular Signal-Regulated Protein Kinase(ERK) in cultured feline ileal smooth muscle cells(ISMC). Western blot analysis done with phospho-specific MAP kinases antibodies demonstrated that potent activation of ERK and moderate activation of SAPK/JNK occurred within 30 min of H$_2$O$_2$ treatment. (omitted)

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