Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.233.2-233.2
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- 2002
DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF APIO ANALOGUE OF NEPLANOCIN A
- Moon, Hyung-Ryong (College of Pharmacy. Ewha Womans University) ;
- Lee, Jeong-Ah (College of Pharmacy. Ewha Womans University) ;
- Yoo, Byul-Nae (College of Pharmacy. Ewha Womans University) ;
- Shin, Dae-Hong (College of Pharmacy. Ewha Womans University) ;
- Jeong, Lak-Shin (College of Pharmacy. Ewha Womans University)
- Published : 2002.10.01
Abstract
Apio nucleosides whose 4'-hydroxymethyl group moves to 3'-position exhibit interesting biological activity such as antitumor or antiviral activity. On the other hand. neplanocin A is the representative of the carbocyclic nucleosides and has been recognized as a potent antitumor and antiviral agent. Based on these findings. it was of great interest to design apio neplanocia A which combined the properties of apio nucleosides and neplanocin A. (omitted)
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