Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.229-229
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- 2002
Role of Kupffer Cells in Hepatic Drug Metabolizing Dysfunction during Polymicrobial Sepsis
- Lee, Sang-Ho (College of Pharmacy, Sungkyunkwan University) ;
- Kim, Joo-Young (College of Pharmacy, Sungkyunkwan University) ;
- Eum, Hyun-Ae (College of Pharmacy, Sungkyunkwan University) ;
- Lee, Sun-Mee (College of Pharmacy, Sungkyunkwan University)
- Published : 2002.10.01
Abstract
Although hepatocellular dysfunction occurs during sepsis. the mechanism responsible for this remains unclear. Since Kupffer cells provide signals that regulate hepatic response in endotoxin and inflammation. the aim of this study was to investigate the role of Kupffer cells in the alterations in the hepatic microsomal drug metabolizing function during sepsis. Rats were subjected to polymicrobial sepsis by cecal ligation and puncture (CLP)followed by fluid resuscitation. (omitted)
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