대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.228.1-228.1
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- 2002
Pharmacodynamics of anticancer activity of tirapazamine and paclitaxel against human NSCLC
- Park, Jong-Kook (Catholic Research Institutes of Medical Science The Catholic Univ of Korea) ;
- Kang, Jin-Hyoung (Catholic Research Institutes of Medical Science The Catholic Univ of Korea) ;
- Kuh, Hyo-Jeong (Catholic Research Institutes of Medical Science The Catholic Univ of Korea)
- 발행 : 2002.10.01
초록
Hypoxia in solid tumors is known to contribute to intrinsic chemoresistance. Tirapazamine(TPZ). a hypoxia-selective cytotoxin. showed synergism with radiation or cytotoxic agents. Paclitaxel(PTX) is a highly active anti-cancer agent against Non small cell lung cancer(NSCLC), however. due to poor penetration into central hypoxic region of tumor tissue. combination with TPZ has been suggested to enhance its efficacy. (omitted)
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