대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.169-170
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- 2002
Chiral Relevance of Stereoselective Disposition of Proton Pump Inhibitors: Comparision of Lansoprasole to Omeprazole and Pantoprazole
- Shin, Jae-Gook (Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center)
- 발행 : 2002.10.01
초록
It has been well known for the stereoselectivity in pharmacodynamic effects of many xenobiotics including therapeutic agents, which have lead to the development of enantiomer drugs. Compared to pharmacodynamic stereoselectivity, stereoselective pharmacokinetics of each enantiomer has not been seriously considered in the development of enantiomer drugs although many reports have been demonstrated the stereoselective absorption and metabolism of racemic drug (e.g verapamil). (omitted)
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