Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.167-168
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- 2002
Accurate Chiral Discrimination of Acidic- and Amino acidic-Chiral Drugs by Indirect GC and Direct CE Enantiomeric Separation Methods
Abstract
Because of the differences between biological and pharmacological properties of chiral drugs in human body, accurate determinations of their optical purities have been in great need. There are two major approaches in chiral separation: indirect method performed under achiral condition, and direct method under the chiral environment. We have been conducting chiral separation of acidic chiral compounds and also amino acidic chiral compounds employing indirect GC methods and direct CE enantiomeric separation methods. (omitted)
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