한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)

한국생물물리학회 (The Korean Biophysical Society)
권호 표지

Sulfhydryl Oxidation Regulates Cloned Mechanosensitive Two-Pore $K^+$ Channel Expressed in Mammalian Cell Lines

  • Kim, Yangmi (Department of Physiology and Biophysics, College of Medicine, Seoul National University) ;
  • Park, Kyoung-Sun (Department of Physiology and Biophysics, College of Medicine, Seoul National University) ;
  • Earm, Yung-E (Department of Physiology and Biophysics, College of Medicine, Seoul National University) ;
  • Ho, Won-Kyung (Department of Physiology and Biophysics, College of Medicine, Seoul National University)
  • 발행 : 2002.06.01
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초록

Oxidative stress has been considered as a major cause of inducing cell damage, but it is recently recognized that mild oxidative stress or receptor-mediated production of ROS contributes to the regulation of various cellular functions. Several ion channels, such as L-type $Ca^{2＋}$ channels and $Ca^{2＋}$-activated $K^{＋}$ channels, have been shown to be regulated by oxidation of thiol group in their structure, and are suggested to be involved in ROS-sensitive cellular signaling.(omitted)

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