Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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An X-ray Crystallographic Analysis of UDP-N-Acetylglucosamine Enolpyruvyl Transferase from Haemophilus influenzae in Complex with UDP-N-Acetylglucosamine and Fosfomycin

  • Yoon, Hye-Jin (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Ku, Min-Je (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Ahn, Hyung-Jun (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Kim, Hyung-wook (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Suh, Se-Won (School of Chemistry & Molecular Engineering, Seoul National University)
  • Published : 2002.06.01
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Abstract

Peptidoglycan is an extensively cross-linked polymer essential for the integrity of the bacterial cell wall. Many antibiotics act by disruption of its biosynthesis and assembly, several are targeted against the cytoplasmic enzymes that synthesize the key intermediate UDP-N-acetylmuramyl pentapeptide. One such drug is fosfomycin, which inactivates the first enzymes in this pathway, UDP-N-acetylglucosamine enopyruvyl transferase (murZ).(omitted)

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