한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)

한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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IN VITRO IMMUNOTOXICITY OF MBP, A MAJOR METABOLITE OF DI-N-BUTYL PHTHALATE(DBP) ON SD RAT SPLENIC B CELLS AND HUMAN B LYMPHOMA CELLS

  • Juno H. Eom (Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Chung, Seung-Tae (Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park, Jae-Hyun (Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Lee, Jong-Kwon (Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Oh, Hae-Young (Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim, Hyung-Soo (Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration)
  • 발행 : 2002.11.01
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초록

Di-n-butyl phthalate(DBP) is one of the most commonly used phthalic acid esters(PAEs) as a plasticizer, a solvent or a component in cosmetic formulations. MBP(monobutyl phthalate) is a major metabolite of DBP. Although DBP has been identified as a reproductive toxicant in several animal species and also known as a endocrine disruptor, the direct or indirect immunomodulatory effect of DBP has been little reported.(omitted)

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