Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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G1 CELL CYCLE ARREST OF KG-1, A HUMAN ACUTE LEUKEMIA CELLS, BY 8-HYDROXYDEOXYGUANOSINE OCCURS THROUGH BLOCKADE OF THE EXTRACELLULAR SIGNAL REGULATED KINASE PATHWAY

  • Hyun, Jin-Won (Department of Biochemistry, College of Medicine Cheju National University) ;
  • Yoon, Sun-Hee (Department of Pharmacology, College of Medicine Seoul National University) ;
  • Yoon, Byung-Hak (Department of Pharmacology, College of Medicine Seoul National University) ;
  • Chung, Myung-Hee (Department of Pharmacology, College of Medicine Seoul National University)
  • Published : 2002.11.01
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Abstract

8-hydroxydeoxyguanosine (oh8dG) potently inhibits proliferation of KG-1, a human leukemia cell line in vitro, but little is known regarding to molecular mechanisms mediating this effect. Here we demonstrate that treatment of KG-1, deficient in 8-oxoguanine glycosylase (OGG1) activity, with oh8dG lead to G1 arrest associated with a dramatic decrease in the levels of cyclin D3 and cyclin-dependent kinase 4 (cdk4) and accompanied by an increase in the expression of p21.(omitted)

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