한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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- Pages.90-105
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- 2002
Agonists of the Dioxin Receptor: Environmental Contaminants, Food Constituents, Microbial Metabolites, and Tumor Promoters
- Schrenk, Dieter (Food Chemistry ＆ Environmental Toxicology, University of Kaiserslautern, Germany)
- 발행 : 2002.11.01
초록
The dioxin- or aryl hydrocarbon receptor (AhR) is a member of the Per-Arnt-Sim family of nuclear transcription factors exhibiting a basic helix-loop-helix structure. In its non-ligated state the AhR is associated with hsp 90 and the immunophilin-type XAP2. Upon ligand binding the associated proteins are released, the receptor dimerizes with the AhR nuclear trans locator protein Arnt, and binds to XREs (xenobiotic-responsive elements) in the 5'-flanking region of responsive genes thus modulating their transcription.(omitted)
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