Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.124-124
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- 2002
ENHANCEMENT OF FREQUENCY OF RADIATION-INDUCED CHROMOSOME ABERRATIONS AND MICRONUCLEI BY ARA C AND 3AB
- Chung, Hai-Won (School of Public Health, Seoul National University) ;
- Cho, Yoon-Hee (School of Public Health, Seoul National University) ;
- Kim, Su-Young (School of Public Health, Seoul National University) ;
- Kim, Tae yeon (School of Public Health, Seoul National University) ;
- Kim, Yang-Ji (School of Public Health, Seoul National University) ;
- Lee, Ra-Mi (School of Public Health, Seoul National University) ;
- Seo, Soo-Ra (School of Public Health, Seoul National University) ;
- Kim, Tae-Hwan (Korea Cancer Center Hospital) ;
- Ha, Sung-Hwan (College of Medicine, Seoul National University)
- Published : 2002.05.01
Abstract
In order to determine the effect of the DNA repair inhibitors, cytosine arabinoside(Ara C)and 3-aminobenzamide(3AB) on the frequenceis of chromosomal aberrations and micronuclei induced by radiation. After in vitro exposure of human lymphocytes to x-ray(1-3Gy) DNA repair inhibitors, Ara C and 3AB were treated and the frequencies of micronuclei, translocation and dicentric chromosomes were analysed using FISH technique with DNA probe for chromosome 4.(omitted)