Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

GENE-SPECIFIC OXIDATIVE DNA DAMAGE IN HELICOBACTER PYLORI INFECTED HUMAN GASTRIC MUCOSA

  • Jinhee Chol (Department of Pharmacology, Seoul National University, College of Medicine) ;
  • Yoon, Sun-Hee (Department of Pharmacology, Seoul National University, College of Medicine) ;
  • Kim, Ja-Eun (Department of Pharmacology, Seoul National University, College of Medicine) ;
  • Rhee, Kwang-Ho (Department of Microbiology, Gyeongsang University, College of Medicine) ;
  • Youn, Hee-Sang (Pediatrics, Gyeongsang University, College of Medicine) ;
  • Chung, Myung-Hee (Department of Pharmacology, Seoul National University, College of Medicine)
  • Published : 2002.05.01
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Abstract

Abstract To study the status of oxidative DNA damage in Helicobacter pylori infection in more details, gene-specific oxidative DNA damage was investigated by examining oxidative DNA damage to individual genes. This was done by determining the loss of PCR product of a targeted gene before and after gastric mucosal DNA was treated with 8-hydroxyguanine glycosylase, which cleaves DNA at the 8-hydroxyguanine residues.(omitted)

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