Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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INDUCTION OF MICROSOMAL EPOXIDE HYDROLASE BY SULFUR AMINO ACID-DEPRIVATION VIA THE PATHWAY OF C-JUN N-TERMINAL KINASE AND ITS EXTRACELLULAR EXPOSURE DURING CELL DEATH

  • Kang, Keon-Wook (National Research Laboratory (MDT), College of Pharmacy, Seoul National University) ;
  • Lee, Chang-Ho (Department of Pharmacology and Institute of Biomedical Sciences, College of Medicine, Hanyang University) ;
  • Kim, Sang-Geon (National Research Laboratory (MDT), College of Pharmacy, Seoul National University)
  • Published : 2002.05.01
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Abstract

Microsomal epoxide hydrolase (mEH), an epoxide detoxifying enzyme and putative cell surface autoantigen, is inducible by xenobiotics and by certain pathophysiological conditions. The present study was designed to determine mEH expression in H4IIE cells during cell death initiated by sulfur amino acid deprivation (SAAD) and to identify the signaling pathway for the enzyme induction.(omitted)

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