Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.73-73
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- 2002
ROLE OF METABOLISM BY FLAVIN-CONTAINING MONOOXYGENASE IN THIOACETAMIDE-INDUCED IMMUNOSUPPRESSION
- Woo S. Koh (Korea Institute of Toxicology) ;
- Lee, Jeong W. (Korea Institute of Toxicology) ;
- Tae C. Jeong (College of Pharmacy, Yeungnam University)
- Published : 2002.05.01
Abstract
Thioacetamide has been known to cause immune suppression. The object of the present study is to investigate the role of metabolic activation by flavin- containing monooxygenases (FMO) in thioacetamide-induced immune response. To determine whether the metabolites of thioacetamide produced by FMO causes the immunosuppression, methimazole (MMI), an FMO inhibitor, was used to block the FMO pathway.(omitted)
Keywords
- thioacetamide;
- cytochrome P450 (P450);
- flavin-containing monooxygenases(FMO);
- immunosuppression;
- metabolic activation