한국환경독성학회:학술대회논문집 (Proceedings of the Korea Society of Environmental Toocicology Conference)
- 한국환경독성학회 2002년도 추계국제학술대회
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- Pages.170-170
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- 2002
The effects of estradiol and its metabolites on the regulation of CYP1A1 expression.
- Euno, Joung-Ki (College of Pharmacy, Ewha womans University) ;
- Yhong, Sheen-Yhun (College of Pharmacy, Ewha womans University)
- 발행 : 2002.10.01
초록
College of Pharmacy, Ewha womans University, Seoul, 120-750, Korea 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent halogenated aromatic hydrocarbon congener that induces expression of several genes including CYP1A1. Exposure to TCDD results in many toxic actions such as carcinogenesis, hepatotoxicity, immune suppression, and reproductive and developmental toxicity. Dramatic differences in dioxin toxicity have been observed between the sexes of some animal species, suggesting hormonal modulation of dioxin action. Many studies have been reported and propose several mechanisms of anti-estrogenic effects of TCDD. In contrast, the effect of estrogen on the regulation of CYP1A1 are not clear at present. There are several reports showing conflicting results. It seems that induction/inhibition of CYP1A1 may be dependent on cell-type and concentration. The purpose of this study was to investigate the regulation of TCDD-induced CYP1A1 gene expression by estradiol and its metabolites. We examined whether estradiol and its metabolites altered TCDD-mediated induction of CYP1A1 enzyme activity. 17