Proceedings of the Korean Society of Embryo Transfer Conference (한국수정란이식학회:학술대회논문집)
- 2002.11a
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- Pages.99-99
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- 2002
Generation of Transgenic Mice Overexpression Mouse RESISTIN
- J. R. Chun (Animal Resource Research Center, Konkuk University) ;
- S. J. Song (Animal Resource Research Center, Konkuk University) ;
- J. T. Do (Animal Resource Research Center, Konkuk University) ;
- K. S. Chung (Animal Resource Research Center, Konkuk University) ;
- Lee, H. T. (Animal Resource Research Center, Konkuk University)
- Published : 2002.11.01
Abstract
The hormone resistin is associated with typeII diabetes mellitus in rodent model. Resistin impairs glucose tolerance and insulin action. A new class of anti-diabetic drugs were called thiazolidinediones (TZDs) downregulates a resistin which is induced during adipocyte differentiation. But the connection between increased adiposity and resistin remains unknown. The objectives of this study was to clone a mouse resistin cDNA and to generate transgenic mice overexpressing mouse resistin gene. The 555 bp of mouse resistin was amplified from mob cDNAS by polymerase chain reaction (PCR) and cloned into pCR