한국감성과학회:학술대회논문집 (Proceedings of the Korean Society for Emotion and Sensibility Conference)
- 한국감성과학회 2002년도 추계학술대회 논문집
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- Pages.148-152
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- 2002
사상관련전위 P300 요소를 이용한 알츠하이머형 치매의 탐지와 분석
Alzheimer Disease detection and analysis using P300 componenet of ERP in Alzheimer type Dementia
초록
This study is to develop the Alzheimers disease (AD) detection and analysis system using event-related potential (ERP) of AD patients. We recorded ERP in an auditory oddball paradigm in mild AD (n=25), severe AD (n=12), age-matched normal aged controls (n=17), and young controls (n=7). The amplitude and latency of target P300 components were compared among 4 groups. The relationship between P300 measures and neuro psychological test (K-DRS) scores were evaluated by correlations. The latency of P300 was prolonged in AD and the effects were correlated with the severity of dementia. The P300 amplitude was not affected significantly in AD. Theres no difference between normal aged group and young group. These results suggest that the P300 component is specifically affected by Alzheimer type dementia.