대한핵의학회:학술대회논문집

The Korean Society of Nuclear Medicine (대한핵의학회)
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Intracoronary Radiation Therapy

관동맥혈관 내 방사선 근접 치료

  • Moon, Dae-Hyuk (Departments of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, Seong-Wook (Departments of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Hong, Myeong-Ki (Departments of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Oh, Seung-Jun (Departments of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Bom, Hee-Seung (Department of Nuclear Medicine, Chonnam Notional University) ;
  • Lee, Hee-Kyung (Departments of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 문대혁 (울산대학교 의과대학, 아산재단 서울중앙병원 핵의학과) ;
  • 박성욱 (울산대학교 의과대학, 아산재단 서울중앙병원 내과) ;
  • 홍명기 (울산대학교 의과대학, 아산재단 서울중앙병원 내과) ;
  • 오승준 (울산대학교 의과대학, 아산재단 서울중앙병원 핵의학과) ;
  • 범희승 (전남대학교 의과대학, 핵의학과) ;
  • 이희경 (울산대학교 의과대학, 아산재단 서울중앙병원 핵의학과)
  • Published : 2001.05.18
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Abstract

Restenosis remains a major limitation of percutaneous coronary interventions. Numerous studios including pharmacological approaches and new devices failed to reduce the restenosis rate except coronary stenting. Since the results of $BENESTENT^{1)}\;and\;STRESS^{2)}$ studies came out, coronary stenting has been the most popular interventional strategy in the various kinds of coronary stenotic lesions, although the efficacy of stenting was shown only in the discrete lesion of the large coronary artery. The widespread use of coronary stenting has improved the early and late outcomes after coronary intervention, but it has also led to a new and serious problem, e.g., in-stent restenosis. Intravascular radiation for prevention of restenosis is a new technology in the field of percutaneous coronary intervention. Recent animal experiments and human trials have demonstrated that local irradiation, in conjunction with coronary interventions, substantially diminished the rate of restenosis. This paper reviews basic radiation biology of intracoronary radiation and its role in the inhibition of restenosis. The current status of intracoronary radiation therapy using Re-188 liquid balloon is also discussed.

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