Toxic Mechanism of Atrazine in Transgenic Mutagenesis System using Big $Blue^{\textregistered}}$Rat2 lacI Transgenic Fibrohlasts And Hormonal Disturbances in vitro

  • Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
  • Lee, Kilchul (National Institute of Environmental Researc) ;
  • Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science & Technology)
  • Published : 2001.05.01

Abstract

Atrazine, one of herbicide widely used in agriculture, is classified as a possible human carcinogen (2B group) that may cause breast and ovarian cancers by IARC, and is known as an endocrine disrupter. Atrazine has been subjected to broad ranges of genotoxicity tests wi th predominantly negative results, but reported conflicting results across two or more independent tests as well. (omitted)

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