Proceedings of the Korea Society of Environmental Toocicology Conference (한국환경독성학회:학술대회논문집)

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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Substrate Specificity of Human Flavin-containing monooxygenase 1 for Thiocarbamides

  • Jung, Ki-Hwa (Dept. of Pharmacy, Duksung Women＇s University) ;
  • D. M. Ziegler (Dept. of Chemistry and Biochemistry, The University of Texas at Austi) ;
  • Kim, Young-Mi (Dept. of Pharmacy, Duksung Women＇s University)
  • Published : 2001.05.01
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Abstract

Microsomes isolated from Spodoptera frugiperda (Sf)9 cells infected wi th human FM01 recombinant baculovirus catalyzed the NADPH- and 02-dependent oxidation of methimazole, thiourea, and phenylthiourea. However there was no detectable activity with 1,3-diphenylthiourea or larger thiocarbamides. Microsomes from control Sf9 cells were devoid of methimazole or thiourea S-oxygenase activity. (omitted)

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