한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)

한국생물물리학회 (The Korean Biophysical Society)
권호 표지

Functional Alterations of Sarcoplasmic Reticulum $Ca^{2+}$ Release Channel in Streptozotocin-induced Diabetic Rat Heart

  • Lee, Eun-Hee (Department of Pharmacology, University of Ulsan College of Medicine) ;
  • Kim, Won-Tae (Dept. Agricultural Chemistry, Chungbuk National Uni) ;
  • Kim, Young-Kee (Dept. Agricultural Chemistry, Chungbuk National Uni) ;
  • Kim, Young-Hoon (Department of Pharmacology, University of Ulsan College of Medicin) ;
  • Kim, Hae-Won (Department of Pharmacology, University of Ulsan College of Medicine)
  • 발행 : 2001.06.01
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초록

Our previous studies showed that the relaxation defect of diabetic heart was due to the changes in the expressional levels of SR $Ca^{2＋}$-ATPase and PLB. In the diabetic heart contractile abnormalities were also observed, and one of the mechanisms for these changes could include alterations in the expression and/or activity levels of various $Ca^{2＋}$ regulatory proteins involving cardiac contraction.(omitted)

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