Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Diabetic Alterations in Cardiac Sarcoplasmic Reticulum $Ca^{2+}$-ATPase and Phospholamban Protein Expression

  • Lee, Hee-Ran (Asan Institute for Life Sciences) ;
  • Cho, Yong-Sun (Department of Pharmacology, University of Ulsan College of Medicin) ;
  • Park, So-Young (Department of Pharmacology, University of Ulsan College of Medicin) ;
  • Kim, Young-Hoon (Department of Pharmacology, University of Ulsan College of Medicin) ;
  • Kim, Hae-Won (Department of Pharmacology, University of Ulsan College of Medicine)
  • Published : 2001.06.01
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Abstract

Diabetic cardiomyopathy has been suggested to be caused by abnormal intracellular $Ca^{2＋}$ homeostasis in the myocardium, which is partly due to a defect in calcium transport by the cardiac sarcoplasmic reticulum (SR). In the present study, the underlying mechanism for this functional derangement was investigated with respect to SR $Ca^{2＋}$-ATPase and phospholamban (PLB, the inhibitor of SR $Ca^{2+}$-ATPase).(omitted)d)

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