Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 2001.06a
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- Pages.40-40
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- 2001
Mechanism of $Zn^{2+}$ Inhibition on Tolaasin Channel Activity
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Cho, Kwang-Hyun
(Department of Agricultural Chemistry, Chungbuk National University) ;
- Kim, Sook-Jin (Department of Agricultural Chemistry, Chungbuk National University) ;
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Kim, Young-Kee
(Department of Agricultural Chemistry, Chungbuk National University)
- Published : 2001.06.01
Abstract
Tolaasin is a 1.9 kDa peptide produced by Pseudomonas tolaasii and causes a brown blotch disease on cultivated oyster mushrooms. These molecules form channels in the plasma membranes of various cells including red blood cells and destroy cellular structure, known as 'colloid osmotic lysis'. In order to understand the molecular mechanism of tolaasin-mediated channel formation, the effect of Zn
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