Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Molecular Cloning and Characterization of Neuronal $\beta$-subunit of Large-Conductance$Ca^{2+}$-activated $K^+$ Channels from Rat Brain

  • Heo, Moon-Sun (Laboratory of Molecular Neurobiology, Department of Life Science, Kwangju Institute of Science and Technology (K-JIST)) ;
  • Ha, Tal-Soo (Laboratory of Molecular Neurobiology, Department of Life Science, Kwangju Institute of Science and Technology (K-JIST) ;
  • Park, Chul-Seung (Laboratory of Molecular Neurobiology, Department of Life Science, Kwangju Institute of Science and Technology (K-JIST))
  • Published : 2001.06.01
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Abstract

We cloned the cDNA encoding the neuron-specific $\beta$-subunit ($\beta$4) of large-conductance calcium-activated potassium channels from rat brain and determined the DNA sequences of the entire coding region (GenBank accession; AY028605). The deduced amino acid sequences of r$\beta$4, 210 amino acids in length, are closely related to the $BK_{Ca}$ $\beta$4 subunits of other species but show only limited sequence homology to other $\beta$-subunits, $\beta$1-$\beta$3.(omitted)d)

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