Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Alteration of Ion Selectivity by Mutations within the Pore-forming Region of Small Conductance $Ca^{2+}$-activated $K^+$ Channels

  • Heun Soh (Laboratory of Molecular Neurobiology, Department of Life Science, Kwangju Institute of Science and Technology (K-JIST)) ;
  • Park, Chul-Seung (Laboratory of Molecular Neurobiology, Department of Life Science, Kwangju Institute of Science and Technology (K-JIST))
  • Published : 2001.06.01
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Abstract

Small conductance $Ca^{2＋}$-activated $K^{+}$ channels (or S $K_{Ca}$ channels) are a group of $K^{＋}$-selective ion channels activated by sub-micromolar concentrations of intracellular $Ca^{2＋}$ independent of membrane voltage. We expressed a cloned S $K_{Ca}$ channel, rSK2, in Xenopus oocytes and investigated the monovalent cation selectivity of the channels. We have used site-directed mutagenesis and macro-channel recordings to identify amino acid residues influencing the ion selectivity.(omitted)d)

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