한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)
- 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
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- Pages.34-34
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- 2001
An Anti-apoptotic Protein Human Survivin is a Direct Inhibitor of Caspase-3 and -7
- Sejeong Shin (National Creative Research Initiative Center for Biomolecular Recognition, Department of Life Science, and Division of Molecular and Life Science, Pohang University of Science and Technology) ;
- Oh, Byung-Ha (National Creative Research Initiative Center for Biomolecular Recognition, Department of Life Science, and Division of Molecular and Life Science, Pohang University of Science and Technology)
- 발행 : 2001.06.01
초록
Survivin, an apoptosis inhibitor/cell-cycle regulator, is critically required for suppression of apoptosis and ensuring normal cell division in the G2/M phase of the cell cycle. It is highly expressed in a cell cycle-regulated manner and localizes together with caspase-3 on microtubules within centrosomes. Whether survivin is a physiologically relevant caspase inhibitor has been unclear due to the difficulties with obtaining correctly folded survivin and finding right conditions for inhibition assay.(omitted)
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