한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)
- 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
- /
- Pages.21-21
- /
- 2001
Crystal Structure of PDZ Domains, Protein Interaction Modules
- Park, Seong-Ho (Dept. of Life Science, Kwangju Institute of Science & Technology (K-JIST)) ;
- Im, Young-Jun (Dept. of Life Science, Kwangju Institute of Science & Technology (K-JIST) ;
- Soyoung Yang (Dept. of Biological Sciences, Korea Advanced Institute of Science & Technology (KAIST) ;
- Kim, Eunjoon (Dept. of Biological Sciences, Korea Advanced Institute of Science & Technology (KAIST) ;
- Eom, Soo-Hyun (Dept. of Life Science, Kwangju Institute of Science & Technology (K-JIST))
- 발행 : 2001.06.01
초록
PDZ domains are molecular-recognition elements that mediate protein-protein interactions. The PDZ domain was discovered originally as a common motif present in three structurally related proteins: PSD-95 (postsynaptic density protein), Dlg (discs-large protein) and ZQ-1 (zonula occludens-1). The PDZ domain is globular domain, containing about 80-100 amino acids, and a conserved motif with two alpha helices and six beta strands. Most of them bind selectively to the C-termini of the interacting proteins at the complexes of signaling molecules and membrane associated receptors.(omitted)
키워드